The result is a documentary that exposes them for public scrutiny without pausing to really interrogate their actions.ĭirected by Skye Borgman, Abducted in Plain Sight begins in the early 1970s in Pocatello, Idaho. And the Broberg family, confessional to a fault, are primed more for honesty than for self-inspection. It unpacks too many bizarre events in a short time frame to allow for much additional analysis. Part of the problem is that Abducted in Plain Sight, a 90-minute movie in a field populated mostly with six- or eight-hour series, is focused entirely on telling a story rather than illuminating it. That is the only reason we told our story. They’re the bravest people I know, willing to try to help the rest of you see what they didn't. It happened to my whole family, this man was a master and my parents saved my life. Manipulation and grooming are not understood by so many. Jan-now Jan Broberg Felt, an actor who’s appeared in Criminal Minds and Everwood-has subsequently defended her mother and father. Much of the outrage targets Jan’s parents, who participated fully in the documentary, and whose behavior in response to Berchtold’s prolonged abuse of their daughter strikes many viewers as shockingly inadequate at best. Over the past week, viral tweets and Reddit threads and various expressions of incomprehension have batted around the internet, as viewers try to make sense of what exactly they’ve just watched. Now I won’t be able to sleep.”Ībducted in Plain Sight was first released as a documentary in 2017 with the title Forever ‘B,’ but it’s gained rather more traction this month after being added to Netflix’s true-crime library. “Oh my goodness,” Mary Ann replies, in a steady, even tone, as if he’s just told her that seasonal allergies might be worse than usual this summer, or that two people brought potato salads to the potluck. That friend, Robert Berchtold, calls Jan’s mother, Mary Ann, and falsely tells her that Jan is prostituting herself and selling drugs. The Oinkari Basque Dancers also performed at Liberty Island later in the afternoon.One of the scenes in Abducted in Plain Sight that best encapsulates the strangeness of its story comes midway through, after the second time a teenager named Jan Broberg has been kidnapped by a close family friend. Performances by the Biotzetik Basque Choir followed. The ribbon cutting was performed by Patricia Lachiondo, President of the Basque Museum & Cultural Center and Guillermo Echenique, General Secretary of Foreign Action of the Basque Government. "Hidden in Plain Sight” opened on February 6 with a special ceremony in the Great Hall at Ellis Island with performances by the Biotzetik Basque Choir, the Oinkari Basque Dancers, and soloist Amaia Arberas. This exhibition was organized by the only museum in the United States devoted to preserving Basque culture and history, The Basque Museum & Cultural Center, in conjunction with and supported by the Basque Autonomous Government. Today, even though Basque politicians, scientists, sports figures, business executives, artists, and movie stars may be prominent throughout the US and in many nations around the world, they are still often overlooked as being Basque, perpetuating them being "Hidden in Plain Sight." In many cases they were simply listed as Spanish or French. Similarly, as they passed through Ellis Island, their nationality, names, and heritage were often disregarded by otherwise well-meaning officials. "Hidden in Plain Sight" was an interactive exhibit that presented opportunities for all ages to discover the unique origins, language, and history of the Basque people the factors that pulled them away from their homes the legendary tales of colorful immigrants Basque contributions in the United States and the world and the unprecedented cultural connection with their homeland.īasques have rarely been recognized for their historic contributions or cultural distinctiveness.
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A Meta spokesperson declined to comment on the plans. The post said they would be notified about their status with the company by early Wednesday morning, one of the sources said. Employees were informed of the layoffs in a post on Meta's internal discussion forum Workplace on Tuesday. Meta is planning to lay off employees on Wednesday in the unit of its metaverse-oriented Reality Labs division focused on creating custom silicon, two sources familiar with the matter told Reuters on Tuesday. Personal Loans for 670 Credit Score or Lower Personal Loans for 580 Credit Score or Lower Free trial for first time customers only.īy purchasing Pro, you acknowledge and agree to the Terms and Conditions, and the Privacy Policy.Best Debt Consolidation Loans for Bad Credit Your payment will auto-renew unless you cancel at least 24 hours before your next renewal date.Your free trial will convert to an auto-renewing subscription unless you cancel at least 24 hours before the trial period ends.Cancel or manage your subscription in your Account Settings.Any unused portion of a free trial period, if offered, will be forfeited when the user purchases a subscription to that publication, where applicable.Subscriptions may be managed by the user and auto-renewal may be turned off by going to the user's Account Settings after purchase.Subscriptions purchased through the app are charged to your iTunes account.Subscribe today to lock in these sale prices!.$3.99/month, billed monthly - NOW $1.99/month.Use all premium images in the meme image libraryįor a limited time, all subscriptions prices are now 50% off!!.Customize the font, position, rotation, and color Add your own watermark, use text or image.Add infinite images and text labels to a meme.Make video memes! Use videos from your album or from popular apps and sites. Add an image or text watermark - use your logo as a watermark!.Add your own watermark, customize font size and color.Choose any background color for your meme!ĬUSTOM WATERMARK (requires Pro, see below for details).Modify the caption font size and the font color.Choose from dozens of fonts for your caption.Resize, crop and reposition the video or image.Access to some templates requires Pro, see below for details.Preset Templates: Is This a Pigeon, Drake, Expanding Brain, Distracted Boyfriend, Nut Button, Last Exit, Night Mode.FREE Templates: Text based, Advice Animal, Top and Bottom Text, Bottom Text Only.Multi-image templates! Vertical side by side, horizontal side by side, 4 images in a square, and more!.Multi-label template: Make any meme that has multiple labels.Browse our Meme Images Library with hundreds of images. VIDEO SEARCH AND TRIM (video requires Pro, see below for details)
However, we’ve picked the first one i.e., as it comes in the first spot on the search results. So, here is how you can copy text from pictures using this way:ġ.Open any browser and search for ‘image to text tool’Ģ.The search engine will bring several results for this query. And for that, we’ll have to explore search engines because most dedicated tools to extract text from images are web apps. The first way involves the use of a reliable OCR tool. 1.Using a Reliable Image to text Converting Tool On the other hand, some businesses rely on online tools and apps to extract text from images. A worthy addition for foreign language learners or people who have trouble reading. So, now, you’ll find multiple ways to copy text from images.įor instance, some organizations invest in developing their own image-to-text translating systems because of high demand and security. You can have TextSniper make Mac read text from image whenever you need it. OCR technology has become increasingly popular, especially in corporate fields. And that’s how the accurate text conversion from pictures into a machine-readable format happens. Once patterns are analyzed, this technology uses machine learning algorithms to compare and match those patterns with known characters and words. Those patterns correspond to typography, such as letters, numbers, and other characters. OCR technology analyzes pixels and patterns in an image. If the image is not clear enough, you can enhance the image with software.īut how does the OCR technology perform accurate conversions? Let’s find out the answer to this question here. The documents can be in pictures, scanned documents, or other electronic forms. OCR enables machines to convert printed or handwritten text from documents into machine-readable formats. The technology used for copying text from images is Optical Character Recognition ( OCR ). How Does the Text Extraction From Digital Documents Happen? But first, we’ll briefly discuss the technology responsible for carrying out the entire image-to-text conversion process. Here, we’ll share the various ways of extracting text from images. And if you are, this blog post is ideal for you. Then, you will see the tools on the results pages. The first step in this whole process is to go to a search engine like Google or Bing and search extract text from image. If this scenario represents your use case, you’ll be looking for a way to optimize the process of copying text from images. There are following steps you have to take are as follows: 1. But the text is so long that the entire process can become arduous if you start typing it manually. Sieracki, 76, of Keene, New Hampshire passed away peacefully on October 1, 2023, at the Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire.Ĭindi was born in Meriden, Connecticut, the daughter of the late Edward and Josephine (Kowalski) Sieracki. All services are under the care of Cheshire Family Funeral Home and Crematories, 46 South Winchester St., Swanzey, NH 03469. A private burial will take place at a later time. Ruck-Up is a local organization dedicated to providing counseling and advocating for Veterans and was instrumental in getting Bob the help he needed after a long battle with PTSD and depression following his service in Vietnam. In lieu of flowers, the family kindly requests that donations be made in Bob’s name to Ruck-Up, Inc. He is also survived by his three siblings, Wilfred Richard, Jane McDonald and her husband Stan, and Sandra Gaudreault and her husband Richard, along with cousins, nieces, nephews, extended family, and friends. Richard, his sons Jeffrey Richard, Gary Dimick, and Rodney Dimick, and daughter Debbie Rock. He enjoyed playing golf, volleyball, fishing, boating, skiing, and riding his motorcycle.īob is survived by his loving wife, Merelyn, their daughter, Michelle E. In his younger years, he was a member of the Jaycees of Claremont and played lead guitar in a band during the 60s. He was the builder of their family home, a member of the Chamber of Commerce, and a devoted member of Littleton Methodist Church. Prior to that, he worked at Butson Supermarkets in Woodsville, NH as the HR Director for 5 years and as the Store Manager for 10 years in Littleton, NH.īob had a multitude of passions and joys in life, with his primary focus being on cherishing moments spent with his family and raising his daughter, Michelle. (Wyman), in a simple service at his sister Sandy’s house in Manchester, NH, surrounded by the love of family and friends–the Richard’s recently celebrated 40 years of marriage.īob was the owner and operator of Top of the Hill Store in Dalton, NH for 15 years until he retired in 2011. On April 29, 1983, Bob exchanged vows with the love of his life, Merelyn A. He served as a Stock Control and Account Specialist and was honorably discharged at the rank of Specialist 5-E5 on November 29, 1973. Bob graduated from Claremont High School in the class of 1967 and continued his education at Loras College in Dubuque, IA, and later at UNH in Durham, NH, where he earned his Bachelor’s in Business Administration in 1973.īob honorably served in the United States Army during the Vietnam War, earning several commendations including the National Defense Service Medal, Vietnam Service Medal with 2 bronze stars, Republic of Vietnam Campaign Medal, Army Commendation Medal, Bronze Star Medal, and Sharpshooter Rifle. Richard on August 18, 1949, in Claremont, NH. Richard, 74, of Swanzey, NH and formerly of Littleton, NH, passed away peacefully on Friday, September 1, 2023, at Ridgewood Center in Bedford, NH after a brief period of declining health. Not sure what to do next in your genealogy research? Get some new ideas by using our Ancestor Source Finder tool.Robert “Bob” F. Walpole: Newhampshire and Vermont Journal, Or, the Farmer's Weekly Museum. Walpole: Newhampshire Journal, Or, the Farmer's Weekly Museum. Walpole: Farmer's Weekly Museum Newhampshire and Vermont Journal. Walpole: Farmer's Museum, or Lay Preacher's Gazette. Walpole: Farmer's Museum, Or, Literary Gazette. Walpole: Farmer's Museum, Or, Lay Preacher's Gazette. Keene: New-Hampshire Recorder and the Weekly Advertiser. Keene: Columbian Informer, Or, Cheshire Journal. Keene: Cheshire Republican and Farmer's Museum. Keene: Cheshire Republican Keene Free Press. Keene: Cheshire County Republican and Farmers' Museum. (Monadnock, N.H.) 1908-1909įitzwilliam: Monadnock Breeze. (Paper-Mill Village, N.H.) 1845-1840sĪlstead: Cold River Journal. For more information on how to locate offline newspapers, see our article on Locating Offline Newspapers.Īlstead: American Citizen, and Militia Advocate. Political Observatory to Genealogy BankĪccording to the US Newspaper Directory, the following newspapers were printed in this county, so there may be paper or microfilm copies available. Newhampshire Journal, or, the Farmer's Weekly Museum to Genealogy Bank Democratic Republican to Genealogy Bankįarmer's Museum or Lay Preacher's Gazette 1799-1801 įarmer's Museum or Literary Gazette 1799-1801 įarmer's Weekly Museum to Genealogy Bankįarmer's Weekly Museum: Newhampshire and Vermont Journal 1797-1799 Choose a large brush size and add three or four shapes. I used the Crosshatch 1 brush located in the Assorted Brushes folder. You will add some variety to the shapes in the next step. The left bracket key ( ) makes the brush larger.ĭon’t add too many brushstrokes. You can change the brush size in the Options bar or use the bracket keys. Place the shapes randomly across the canvas.Ĭhange the brush size and add a few more brushstrokes. Click on the white background layer and add three or four shapes. Some are free, and others you must purchase.Ĭhoose a large brush size. A dense center will pull the eye.Īlso, you can download other brushes from the web. You can also use a soft round brush for a circular shape. Shapes like diamonds and triangles also work well as part of the sparkle brush. Here are some favourites:įeel free to experiment with other brushes. For my sparkle brush, I started with the Star 70 brush located in the Default Brushes folder. There are many other options available in the Legacy Brush folder. In the Options bar on top of the workspace, choose a star-shaped brush from the Brush Preset picker. Adding color to the texture and applying it to text or symbols takes only a few additional clicks.Click on the Brush tool in the toolbar. It is easy to create a glitter texture in Photoshop. This determines how much the texture will fade. Experiment with where you start and end the gradient. Drag up in your canvas to apply a gradient. Or go to the Layer drop-down menu and select Layer > Layer Mask > Reveal All.Īdd a gradient to the layer mask by selecting the Gradient tool from the toolbar. At the bottom of the Layers panel, click the Layer Mask icon. Select Layer > Merge Layers (Ctrl or ⌘E). Step 1: Merge Layers and Add a Layer Mask The texture fades out, creating an ombre effect (colors and tones shade into each other). You can make a glitter gradient in Photoshop by using a layer mask. To let the text show through, highlight the Color Fill layer and go to the Layer drop-down menu. This applies the color to the layers below. Step 3: Drag the Color Fill layer to the Topĭrag the Color Fill layer to the top of the Layers panel. Choose from shapes in the options menu (more shapes are available online to download.) Merge layers with text and symbols into one. Or open the Shape tool menu and select the Custom Shape tool. Highlight both layers and go to the Layer drop-down menu. To apply the glitter texture to text or a symbol, merge the Color Fill and Texture layer. Gold glitter texture How to Add Glitter to Text or Symbols Step 1: Merge Layers Soft Light will give you a lighter effect.ĭouble click the Color Fill layer to change the color. Change the blend mode to Color Burn or Soft Light. To make gold glitter, type FFD700 next to the # symbol. In the Color Picker (Solid Color) window, select the color you want to use as the basis for your glitter. Select Layer > New Fill Layer > Solid Color. Name your color layer. To add color to your glitter texture, open the Layer drop-down menu. How to Add Color to the Glitter Texture Step 1: Add Fill Layer You can add glitter any time you want! You can also access your pattern from other tools like the Paintbrush and Paint Bucket. Your new glitter pattern should be at the bottom. In the Fill window, set Contents to Pattern. Open a new file or a new layer. Go to the Edit drop-down menu. Your glitter pattern in Photoshop is ready to use. Highlight all layers ((hold Ctrl or ⌘) and go to the Layer drop-down menu. Monochromatic glitter texture Step 1: Merge Layers We will add color in a moment.īut first, let’s save the texture as a glitter pattern in Photoshop. Saving your glitter texture as a pattern will let you access it any time you want. That’s it! You have created a glitter texture. Set the blend mode to either Multiply or Color Burn. Go to Edit > Transform > Rotate 90 Clockwise. If you want a denser texture to your glitter, copy the original layer again. You can experiment with other blend modes like Color Burn or Overlay. In the Layer Style window, change the blend mode to Multiply. Go to Edit > Transform > Rotate 180.ĭouble click on the duplicate layer. Open the Layer drop-down menu and select Layer > Duplicate (Ctrl or ⌘J). To add fullness to the texture, copy the background layer. In the Crystallize window, set the cell size to 5. Check the Monochromatic box.Īdd a Crystallize filter to the noise layer by going to the Filter drop-down menu. In the Add Noise window, set the amount to 50% and select Uniform. Choose a white background.Īdd noise to the background layer by going to the Filter drop-down menu. Go to the File drop-down menu and select File > New. Start by opening a new document in Photoshop. Creating a Glitter Effect in Photoshop: How to Create a Glitter Texture Step 1: Open a New Document We’re sure fans will be more than elated to witness and admire these Hikari Mori sexy pictures which are sure to be to their liking and satisfaction! Each and every snap of her is a dedication to her undeniably unbeatable beauty and the same can be seen in these priceless collection of Hikari Mori boobs images. Mori Hikari is a talented model and the younger sister of Mori Izumi. Hikari Mori Sexy Bikini Pics Hikari Mori Sexy Pics Now, months after Mori’s death, his millions are mired in. 20210910Hikari Mori, Paris, Vogue Taiwan screenshot (08m08s) (cropped).jpg. Hikari Mori, best known for being a TV Actress, was born in Tokyo, Japan on Wednesday, April 22, 1992. Now that we’ve given enough information about Hikari Mori, it’s time to move on to our next segment which is what you’ve all been waiting for! Yes! It’s time to immerse yourself and witness the beauty and style of this fashionably glamorous babe, in her many poses and postures in this handpicked selection of Hikari Mori hot pictures galore, exclusively for our visitors and viewers. Eugene Ewan Mori, the former president of the Hialeah Park Race Track in its hey day, built up a 100 million fortune in South Florida. Hikari Mori Hot Pics Hikari Mori Hot Pics View Hikari Mori booking agent, manager, publicist contact info. Year Title Role Rating 2023: Ninosan Special: Ninosan to Asobo add. Hikari Mori management contact details (name, email, phone number). Japanese Movie, 2012, Rie (Main Role) Rie. We introduce how to incorporate the cleanse and the impressions. Her online content made her hugely and one of the most well known Asian figure in the western hemisphere. Year Title Role Rating 2012: Aoi Sora Shiroi Kumo add. This is the interview page of Izumi Mori and Hikari Mori of Juice Cleanse of Sunshine Juice. She started growing in the international career after she worked hard to achieve fame and popularity. Hey guys, I’m Hikari Mori Thanks for watching It’s about time I start my own channel : ) In this channel I’ll be going to share about my roots/ food / lifestyle. Her fame and talent was well appreciated by the audience and her content online has been hugely applauded by the audience. The diamond is the symbol of purity, innocence, eternity and courage. Diamond is a symbol of everlasting love and once was thought to bring courage. She has worked hard to become a model and actress and after she achieved fame she never looked back. Hikari Mori was born in the middle of Millennials Generation. Take a deep breath and think of the camera as someone you love.Hikari Mori is a famous American personality who is extremely talented. The secret to being comfortable in front of the camera is… The items you’ll always find in my carry-on bag are…Įye mask, ankle warmers, tea packs, a banana, 2-3 books and moisturizing masks. Traveling the world – the colors, patterns and national costumes. I am always finding style inspiration in… Linda Rodin, Iris Apfel and Ilona Royce Smithkin. The person whose style I admire the most is… There are no rules in fashion so just try everything and have fun. We caught up with her at Tory’s Fall Winter 2019 show to learn about the secret to great personal style, where she finds inspiration and what’s in her carry on bag. The president, Yoshiro Mori, stoked a social media backlash after news reports emerged of his comments demeaning women during an executive meeting of the Japanese Olympic Committee that was held. When she’s not in front of the camera, she’s a regular in the front row on the NewYork/London/Milan/Paris runway circuit as well as events such as the annual Met Gala and Venice Film Festival. It makes perfect sense that this pixie-haired Japanese-American model and actress has an inimitable sense of style. For Hikari Mori, fashion runs deep – her grandmother is the celebrated couturier Hanae Mori (check out the vintage selection of her gowns on ). Characters from the ASCII character set can be used directly, with a few exceptions (e.g. LaTeX The LaTeX command that creates the icon. means that y y is defined to be 7x + 2 7 x + 2. Articles with usage Examples of Wikipedia articles in which the symbol is used. It is borrowed from computer programming: it means that the item on the left hand side is being defined to be what is on the right hand side. Different possible applications are listed separately. Letters here stand as a placeholder for numbers, variables or complex expressions. Usage An exemplary use of the symbol in a formula. If there are several typographic variants, only one of the variants is shown. Symbol The symbol as it is represented by LaTeX. The following information is provided for each mathematical symbol: Listing of Named Characters Wolfram Language Syntax Characters Relational Operators & Characters Tech Notes. Further information on the symbols and their meaning can also be found in the respective linked articles. Equal NotCongruent GreaterLess Related Guides. A symbol with three horizontal line segments resembling the equals sign is used to denote both equality by definition (e.g., means is defined to be equal to ) and congruence (e.g. Mathematica does not have any built-in connectivity to MATLAB. Equality is transitive, so if and, then it is also true that. Some symbols have a different meaning depending on the context and appear accordingly several times in the list. In Mathematica, the equal sign is reserved for variable assignment, and a. To define a function, just type in the formula. The symbol is used in math to indicate that two expressions are not equal to each. It is divided by areas of mathematics and grouped within sub-regions. This functions can be not only in terms of the internal build-in functions, but also in terms of procedures. The symbol for not equal is an equal sign with a diagonal line through it. The following list is largely limited to non-alphanumeric characters. Many of the characters are standardized, for example in DIN 1302 General mathematical symbols or DIN EN ISO 80000-2 Quantities and units – Part 2: Mathematical signs for science and technology. is an option for functions such as Simplify, Refine, and Integrate that specifies default assumptions to be made about symbolic quantities. As it is impossible to know if a complete list existing today of all symbols used in history is a representation of all ever used in history, as this would necessitate knowing if extant records are of all usages, only those symbols which occur often in mathematics or mathematics education are included. The following list of mathematical symbols by subject features a selection of the most common symbols used in modern mathematical notation within formulas, grouped by mathematical topic. It has been suggested that this article be merged into Glossary of mathematical symbols. The second module is an easy-to-follow course, which includes hands-on examples of solutions to common problems with object-oriented code. By the end of the book, you will understand how reactive JavaScript is going to be the new paradigm. The book will also teach you how to use arrays and objects as data structures. You develop concrete understanding of variable scoping, loops, and best practices on using types and data structures, as well as the coding style and recommended code organization patterns in JavaScript. You will start by getting acquainted with the language constructs and how to organize code easily. The first module will help you master JavaScript and build futuristic web applications. Object-oriented programming, which is popularly known as OOP, is basically based on the concept of objects rather than actions. Using JavaScript, you can create interactive web pages along with desktop widgets, browser, and application extensions, and other pieces of software. JavaScript is the behavior, the third pillar in today's paradigm that looks at web pages as something that consists of : content (HTML), presentation (CSS), and behavior (JavaScript). Design applications using a modular architecture based on SOLID principles.Identify and apply the most common design patterns such as Singleton, Factory, Observer, Model-View-Controller, and Mediator Patterns.Master DOM manipulation, cross-browser strategies, and ES6.Work with a combination of access modifiers, prefixes, properties, fields, attributes, and local variables to encapsulate and hide data.Generate instances in three programming languages: Python, JavaScript, and C#.Learn to build scalable server application in JavaScript using Node.js.Get acquainted with the basics of JavaScript language constructs along with object-oriented programming and its application. JavaScript developers looking to enhance their web developments skills by learning object-oriented programming. Learn the latest ES6 features and how to test and debug issues with JavaScript code using various modern mechanisms.Capture objects from real-world elements and create object-oriented code that.
Other evidence shows that alcohol exposure elicits functional and structural plasticity selectively in D1-MSNs. Further, D1-like antagonists impair alcohol-seeking in an operant task. Pharmacological blockade of D1-like receptors, but not D2-like receptors, attenuates alcohol consumption when delivered in the dorsomedial striatum. Deletion of the gene encoding for D1R ( Drd1a) impairs alcohol drinking and preference. In the striatum, D1R are expressed in the direct pathway medium spiny neurons (D1- MSNs) and regulate the reinforcing properties of alcohol. Thus, LRRK2 is proposed to limit D1R signaling via PKA pathway in the direct-pathway medium spiny neurons of the striatum. Gain-of-function mutations of Lrrk2 were shown to reduce PKA activity. Global deletion of Lrrk2 enhanced protein kinase A signaling downstream of D1R and altered dendritic spine morphology and synaptic strength in striatal medium spiny neurons of developing mice. Mutations in Lrrk2 alter membrane trafficking and surface expression of D1R. LRRK2 was shown to act as a negative modulator of dopamine D1 receptors (D1R) within the striatum. However, it remains unclear whether this association is causal, and which are possible mechanisms underlying the impact of LRRK2 activity on alcohol reinforcement. A positive correlation between striatal levels of Lrrk2 mRNA and alcohol drinking was reported in mice, especially an association with inflexible alcohol drinking that persists despite adverse outcomes or punishment. Recent work has linked changes in striatal expression of the Lrrk2 gene with alcohol drinking in humans and rodents. Mutations in the human LRRK2 gene are associated with Parkinson’s disease, which is characterized by prominent impairment in dopamine signaling and basal ganglia function. The leucine-rich repeat kinase 2 ( Lrrk2) gene is highly expressed in the striatum and plays an important role in regulating synapse formation and synaptic transmission. In fact, functional and morphological alterations in the striatal circuitry have been linked to AUD and we hypothesize that difference in the striatal circuitry can drive vulnerability for developing AUD. The striatum plays a central role in learning and execution of reward-motivated behaviors, making this brain region very relevant for substance use disorders. Only a fraction (~8%) of those who consume alcohol are diagnosed with AUD each year, pointing to the existence of risk and resilience factors for developing the disorder. Loss of control over alcohol drinking leads to abuse and hinders long-term abstinence, driving relapse. These findings identify a potential novel role for LRRK2 function in the striatum in promoting resilience against heavy and persistent alcohol drinking.Īlcohol use disorder (AUD) is a chronic relapsing disorder characterized by an inability to stop alcohol use despite adverse consequences. Mice with cell-specific deletion of Lrrk2 were more prone to heavy alcohol drinking, and consumption was insensitive to punishment. Constitutive deletion of the Lrrk2 gene specifically from D1R-expressing neurons potentiated D1R signaling at the cellular and synaptic level and enhanced alcohol-related behaviors and drinking. Here, we report that the Parkinson’s-related protein leucine-rich repeat kinase 2 (LRRK2) modulates striatal D1R function to affect the behavioral response to alcohol and the likelihood that mice transition to heavy, persistent alcohol drinking. The molecular mechanisms that generate vulnerability in some individuals to undergo the transition are less understood. This transition requires long-lasting changes in the synaptic drive and the activity of striatal neurons expressing dopamine D1 receptor (D1R). The transition from hedonic alcohol drinking to problematic drinking is a hallmark of alcohol use disorder that occurs only in a subset of drinkers. In June 2016, the service platform launched in Indonesia, collaborating with market leaders IndiHome, Telkom Indonesia. In March 2016, the CATCHPLAY+ service platform made its pilot launch in Taiwan in partnerships with major telecommunication operators and device manufacturers. In addition to content aggregation, in 2015, CATCHPLAY established AsiaPlay Incorporated with the ambition of becoming the leading premium content service provider for movie lovers in Asia. Today, we are the largest provider for premium movie content in Taiwan, aggregating content from Hollywood studios including Disney, Warner Bros., NBC Universal and Paramount in addition to having a wide selection of international independent films and leading local productions for distribution on major operators’ digital platforms. Today, CATCHPLAY continues to look into investment and co-production opportunities internationally and in Asia targeting particularly Chinese-speaking territories and South East Asia following our recent expansion footprints.ĬATCHPLAY started placing significant emphasis on the development of digital movie content years before the others did in Taiwan. In the same year, CATCHPLAY also provided financing and local production support to director Martin Scorsese’s passion project Silence, making it the first international production filmed entirely in Taiwan. CATCHPLAY and partners also control exclusive distribution rights to these films in Taiwan, China, Hong Kong and Macau, with The Revenant generating outstanding box office results from these territories in 2016. In early 2015, we closed a partnership deal to invest in New Regency’s three enthralling titles, namely The Revenant, Assassin’s Creed and Splinter Cell, marking the first investment of a Taiwanese company in major Hollywood productions. Both investments generated considerable box office performance in Taiwan and China respectively. In the same year, we invested in the locally produced film, Paradise in Service and co-produced 20 Once Again with CJ Entertainment for the Chinese market. Here’s a few more you should check out (and where to watch them).In 2014, in addition to distributing the movies CATCHPLAY loves, we embarked in earnest co-production and investment projects, venturing into content creation. The above movies are really devoted primarily to what is available on Netflix, but Ana de Armas has starred in many other excellent films. De Armas and Izzo play a pair of stranded young women with a sinister agenda in mind when they seek refuge with married man (Reeves). As a horror/thriller film though, Knock Knock leaves a lot to be desired.Īs much as we love Keanu, his performance in this is pretty bad and the movie itself is just a hot mess. It’s a remake of the 1970s movie Death Game from director Eli Roth, which might give you an idea of what to expect. SKIP! – This 2015 thriller was one of De Armas’ early notable roles and co-stars Keanu Reeves and Lorena Izzo. Initially released at Sundance, Sergio is technically a Netflix Original after the streamer received distribution rights. WATCH! – Sergio is a 2020 film following the UN diplomat Sérgio Vieira de Mello (Wagner Moura), who must fight for survival after a bomb blast. The film follows a CIA asset on the run from assassins working for one of his former colleagues. Besides De Armas, the film also stars Chris Evans and Ryan Gosling, so the cast is worth watching for, but this also isn’t a movie that needs to be at the top of your watchlist. SKIP! – The Gray Man is one of Netflix’s biggest action movies, an action-thriller from Marvel vets Anthony and Joe Russo. It’s not the most groundbreaking thriller in the genre, but it’s serviceable and all of the actors do a great job, especially Kinnaman and the female lead, Rosamund Pike. The Informer is a 2019 crime thriller film following a soldier (Kinnaman) on a cover assignment to take down a crime boss. Here, she plays Joel Kinnaman’s wife, Sofia Koslow. In movies like this and War Dogs, she was mostly relegated to the wife/girlfriend role. WATCH! – Prior to her breakout part in Knives Out, many of De Armas’ roles were on the thinner side and The Informer is a good example of that. |
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